ABSTRACT
Objectives: To analyze antiphospholipid antibodies in women with recurrent spontaneous abortion
Study design: A Case-control study
Place and duration: Isra University and Liaquat University of Medical and Health Sciences Jamshoro from 1st June to 31st December 2010
Methodology: Sixty three subjects with history of three spontaneous abortions in their first three months of pregnancy were included in this study and 63 women of corresponding age, with one or more alive babies having no record of any first trimester spontaneous abortion were taken as controls. Coagulation tests platelet count, prothrombin time and activated partial thromboplastic time were done by standard methods. Antiphospholipid Antibodieswere estimated by ELISA method using specific kits
Results: Mean serum Antiphospholipid antibodies level was 7.10 +/- 3.47 in patients and 6.30 +/- 2.02 in controls. The difference in serum level of two groups was significant. Mean platelet count; mean prothrombin time and activated partial thromboplastin time revealed no significant difference between patients and controls
Conclusion: There is strong association of antiphospholipid antibodies in the patients having recurrent spontaneous abortions so there is a strong need of including this test in the primary screening of such disease in the pregnant women who have history of previous abortion
ABSTRACT
Objectives: Recognition of fatal coagulopathies in patients with carcinoma of prostate by carrying out platelet count, PT and APTT
Study Design: A case-control study
PLACE AND DURATION: Samples collected from patients attending ISRA University Hospital, Hyderabad, Liaquat University of Medical and Health Sciences Hospital Hyderabad and NIMRA Jamshoro from June 2011 to November 2011. Study was conducted in the Pathology department, ISRA University Hospital, Hyderabad. Duration of study was six months
Methodology: Cases were patients with prostatic carcinoma who were diagnosed on biopsy examination. Controls were normal healthy randomly selected age matched adult males from Hyderabad without prostatic carcinoma. A total of one hundred subjects were included in the study. They were divided in two groups as follows; Group-I: Patients-Diagnosed cases of carcinoma of prostate. Group - II: Control - Normal subjects of the same age group
Results: A total number of 50 cases with the history of prostatic carcinoma were included according to the criteria mentioned in the material and method section. The frequencies of different variables were taken for platelet count, prothrombin time and activated partial thromboplastin time. In Group -1 [Cases], the mean platelet count was 197.52 x 10[3] in patients with advance age and in Group - II [Controls], the mean platelet count was 286.06 x 10[3]. The mean platelet count of cases and control is shown in Table -1.In the Group -1 [Cases] the mean PT value was 16.95 seconds and in Group - II [Controls] the mean PT value was 11.92 seconds. The mean PT of cases and control is shown in Table - II. In the Group -1 [Cases] the mean APTT value was 36.88 seconds and in Group - II [Controls] the mean APTT value was 30.94 seconds. The mean APTT of cases and control is shown in Table-III
Conclusion: Early analysis and recognition of coagulopathies in patients with carcinoma of prostate by carrying out platelet count, PT and APTT should be sorted out to help the patients in terms of treatment or diagnosis or prevention of fatal complications. Disseminated intravascular coagulation is the most frequently reported disorder but, in spite of its long-time recognition, its treatment remains controversial. Our results suggest that platelet count; PT and APTT are altered in patients with prostate cancer. Further study is needed to elucidate the underlying mechanism and clinical significances of such a phenomenon among patients with prostate cancer
ABSTRACT
Analysis and recognition of coagulopathies in patients with carcinoma of prostate by carrying out platelet count and D-dimers level. Case-control study. This study was conducted at ISRA Hospital, Hyderabad, Liaquat University of Medical and Health Sciences Hospital Hyderabad and NIMRA Jamshoro for a period of six months from from June 2011 to November 2011. Cases were patients with prostatic carcinoma who were diagnosed on biopsy examination. Controls were normal healthy randomly selected age matched adult males from Hyderabad without prostatic carcinoma. A total of one hundred subjects were included in the study. In Group I [Cases], the mean platelet count was 197.52 x 103 and in Group II [Controls], the mean platelet count was 286.06 x 103. In Group I [Cases], the mean D-dimers level was 0.692 mg/L and in Group II [Controls], the mean D-dimers level was 0.146 mg/L. Coagulopathies are frequently associated with prostate cancer and should be known to urologists and oncologists because they may compromise short-term prognosis and influence therapeutic strategies. Our results suggest that platelet count and D-dimer levels are altered in patients with prostate cancer
ABSTRACT
To study the frequency and pattern of benign, premalignant, and malignant lesion in hystrectomized uteri and perform clinic-pathological analysis. All hysterectomy specimens received in the histopathology departments of Isra University Hyderabad and Liaquat University of Medical and Health Sciences Hyderabad during the period of January 2005 to December 2006 were studied. A randomized study of 100 cases undergoing hysterectomy was carried out and clinicopathological analysis was done. Most women who underwent hysterectomy were in the age group of 25-75 years. Two proformas were designed to record the clinical information and gross and histopathological findings. Specimens were preserved in 10% formalin and thorough gross examination was done. Representative blocks were processed for paraffin embedding. Abnormal menstrual flow was the most common complaint. Mean age of the patient was 43.06 +/- 7.34 years. Out of 100 cases, endometrial diseases were the most common finding [in67% of the cases] followed by adenomyosis [47%], leiomyoma [32%], cervical intraepithelial neoplastic changes [04%], and invasive cervical carcinoma [03%]. This study concludes that benign uterine lesions are common, consisting mostly of endometrial hyperplasia, leiomyoma, and adenomyosis, and are almost equally present in women above and below the age of 40 years in Hyderabad with the exception of endometrial carcinoma and invasive cervical carcinoma which were commonly found above 40 years of age
Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Age Distribution , Leiomyoma/surgery , Endometrial Hyperplasia/surgery , Uterine Cervical Neoplasms/surgery , Carcinoma, Endometrioid/surgeryABSTRACT
Teaching of biomedical ethics as a part of curriculum to undergraduates of medical universities is in practice in western countries for many decades. It has been started in some Pakistani medical institutes as well. The objective is to make them aware and prepare for recognizing ethical issues and dilemmas in their clinical rotations. This study was conducted in three medical colleges of province of Sindh to find out how well informed and practical they are in terms of identifying and approaching ethical issues. The study was based upon questionnaire response to problems related to patients rights, ethical dilemma etc. The participants included 421 medical students and 101 postgraduate trainees. The results showed significant difference in identifying ethical dilemmas, where medical students who had been taught as what they are, easily recognized them while most of the postgraduate students failed to do so. It is thus concluded that ethics as a subject must be incorporated in medical curriculum both at under and postgraduate level
Subject(s)
Humans , Education, Medical/ethics , Bioethics , Teaching/ethics , Students, MedicalABSTRACT
Myocardial infarction is a major consequence of coronary artery disease. Recently many reports have been suggested that hyperhomocysteinemia had an important role in myocardial infarction. Plasma homocysteine level was determined in 60 myocardial infarction patient [Group A] and 35 healthy controls [Group B]. Statistically significant difference was observed in plasma homocystine concentrations between the patients of acute myocardial infarction [Group A] and in normal healthy individuals [Group B]. The level of homocystine in patients of myocardial infraction is significantly increased when compared with controls. This indicates a strong association between hyperhomocysteinemia and acute myocardial infraction in the peoples of Hyderabad, thus showing plasma homocysteine as a risk factor for myocardial infarction